Uncle Tom is the title character of Harriet Beecher Stowe's 1852 novel, Uncle Tom's Cabin.

Uncle Tom may also refer to:

• Uncle Tom (film), a 2020 documentary film about Black conservatism in the United States
• Uncle Tom syndrome, a psychological coping skill in which individuals use passivity and submissiveness when confronted with a threat
• Uncle Tom Cobley, a humorous placeholder name in British English

• Uncle Tom's Cabin (disambiguation)