U.S. Route 5 (US 5) is a north–south United States Numbered Highway extending from southern Connecticut to the northernmost part of Vermont. In Massachusetts, the route travels 53.46 miles (86.04 km), paralleling the Connecticut River and Interstate 91 (I-91) through Hampden, Hampshire, and Franklin counties.

US 5 stays very close to the Connecticut River and I-91. It enters the state at the town of Longmeadow on the east bank of the river going up to Springfield. In Springfield, US 5 then overlaps with I-91 for about 0.5 miles (0.80 km) and then separates as its own freeway crossing the Connecticut River on the South End Bridge into Agawam. The freeway portion travels for about 3.3 miles (5.3 km) up to West Springfield. From the town of Northampton up to Bernardston, US 5 travels concurrent with Route 10 for 26 miles (42 km). US 5 also passes through Holyoke, Hatfield, Whately, Deerfield, and Greenfield. As in Connecticut and Vermont, US 5 has many interchanges with the parallel I-91.

County	Location	mi[1]	km	Destinations	Notes
Hampden	Longmeadow	0.00	0.00	US 5 south – Enfield, Hartford	Continuation into Connecticut
		1.80	2.90	Route 192 south – East Longmeadow, Stafford Springs, CT	Northern terminus of Route 192
	Springfield	3.50	5.63	I-91 south – Hartford, CT	Southern end of I-91 concurrency; exit 1 on I-91
		3.70	5.95	Route 83 south – Forest Park, East Longmeadow	Northern terminus of Route 83; exit 2 on I-91
		3.90	6.28	I-91 north – Springfield, Chicopee, Holyoke	Northern end of I-91 concurrency; exit 3 on I-91
	Connecticut River			South End Bridge
	Agawam	4.60	7.40	Route 57 west – Agawam, Southwick	Rotary interchange; Eastern terminus of Route 57
	West Springfield	5.80	9.33	Route 147 west – West Springfield, Agawam, Southwick	Rotary interchange; eastern terminus of Route 147; to Memorial Bridge
		7.00	11.27	US 20 – Westfield, Springfield	Rotary interchange
		9.30	14.97	I-91 to I-391 north – Holyoke, Springfield	Exits 10A-B on I-91
		10.80	17.38	I-90 / Mass Pike / I-91 – Holyoke, Springfield, Albany, NY, Boston	Exit 45 on I-90 / Mass Pike; exit 11 on I-91
	Holyoke	13.80	22.21	US 202 to I-91 – Westfield, Southwick, South Hadley
		14.60	23.50	Route 141 east – Holyoke Center, Chicopee Falls	One-way eastbound
		14.80	23.82	Route 141 west to I-91 – Easthampton, Greenfield, Springfield	One-way westbound
		15.00	24.14	To US 202 north – South Hadley Falls, Athol	Access via Lincoln Street
Hampshire	Northampton	21.90	35.24	I-91 – Greenfield, Brattleboro, VT, Holyoke, Springfield	Exit 23 on I-91
		22.90	36.85	Route 9 / Route 10 south – Easthampton, Pittsfield, Amherst	Southern end of Route 10 concurrency
		24.30	39.11	I-91 north – Greenfield, Brattleboro, VT	Northbound exit and southbound entrance; exit 26 on I-91
		26.10	42.00	I-91 – Greenfield, Brattleboro, VT	Exit 27 on I-91
	Hatfield	28.65	46.11	I-91 south – Holyoke, Springfield	Exit 30 on I-91
Franklin	Whately	30.50– 31.20	49.08– 50.21	I-91 north – Greenfield, Brattleboro, VT	Exit 32 on I-91
		33.70	54.23	I-91 south – Holyoke, Springfield	Exit 35 on I-91
		33.90	54.56	Route 116 south – Sunderland, Amherst	Southern end of Route 116 concurrency
	Deerfield	34.80	56.01	Route 116 north to I-91 north – Conway, Ashfield	Northern end of Route 116 concurrency
	Deerfield River			Bridge
	Greenfield	42.50	68.40	Route 2A – Athol, Shelburne	Court Square; site of historic road marker
		44.20	71.13	Route 2 to I-91 – Athol, Boston, North Adams, Bernardston, Springfield	Diamond interchange
	Bernardston	49.00	78.86	Route 10 north to I-91 – Northfield, Erving, Keene, NH	Northern end of Route 10 concurrency
		53.46	86.04	US 5 north – Brattleboro	Continuation into Vermont
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access

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U.S. Route 5
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