A train wreck is the aftermath of a train crash.

Train wreck may also refer to:

• Train wreck cluster, an astronomical galaxy cluster, also known as Abell 520
• Trainwreck (film), a 2015 American film
• Trainwreck with Kyle Gass, southern comedic rock band featuring Kyle Gass of Tenacious D
• Trainwreck (band), heavy metal band from Bangladesh
• Trainwreck (album), an album by Boys Night Out
• "Trainwreck" (Banks song), 2016 song from the album The Altar
• "Trainwreck", a song by Mastodon from their album Remission
• "Trainwreck", a song by Demi Lovato from her album Don't Forget
• "Train Wreck" (James Arthur song), a song by James Arthur from the album Back from the Edge
• Trainwreck: My Life as an Idiot, a 2007 film also known as American Loser
• "Train Wreck", an episode of the sitcom The King of Queens
• Trainwreck: Woodstock '99, a 2022 US docuseries about the Woodstock '99 music festival
• Trainwreckstv, an American livestreamer

• Train Wreck Records, an independent record label founded by Chip Taylor
• Trainwreck Circuits, an American boutique guitar amplifier manufacturer
• Train wrecker (Neolentinus lepideus), a mushroom