Tinosporide is a chemical compound classified as a diterpenoid and a furanolactone. It was first isolated from the plant Tinospora cordifolia, from which it derives its name.[1][2] It has since been found in other plants of the genus Tinospora, such as Tinospora glabra.[3] [4] [5]

Because Tinospora cordifolia has been used in traditional herbal medicine, there has been research directed at exploring the potential pharmacology of tinosporide and related compounds.[6]

Other diterpenoid furanolactones with a similar structure include columbin, palmarin, and chasmanthin.

  • Columbin
    Columbin
  • Palmarin
    Palmarin
  • Chasmanthin
    Chasmanthin
  1. ^ Swaminathan, K.; Sinha, U. C.; Bhatt, R. K.; Sabata, B. K.; Tavale, S. S. (1989). "Structure of tinosporide, a diterpenoid furanolactone from Tinospora cordifolia Miers". Acta Crystallographica Section C. 45 (1): 134–136. Bibcode:1989AcCrC..45..134S. doi:10.1107/s0108270188009953. PMID 2610955.
  2. ^ Sharma, Priyanka; Dwivedee, Bharat P.; Bisht, Dheeraj; Dash, Ashutosh K.; Kumar, Deepak (2019). "The chemical constituents and diverse pharmacological importance of Tinospora cordifolia". Heliyon. 5 (9): e02437. Bibcode:2019Heliy...502437S. doi:10.1016/j.heliyon.2019.e02437. PMC 6827274. PMID 31701036.
  3. ^ "Isolation and Characterisation of clerodane diterpenoids from the traditional medicinal plant -Tinospora glabra (Burm. f.) Merrill".
  4. ^ Girme, Aboli; Saste, Ganesh; Singh, Ruchi; Mirgal, Amit; Ingavale, Rajnita; Balasubramaniam, Arun Kumar; Ghoshal, Sautik; Ghule, Chetana; Patel, Saurabh; Verma, Mahendra Kumar; Maurya, Rakesh; Hingorani, Lal (2022). "Quantitative and rapid quality assessment methods for the multi-class bioactive constituents of Tinospora cordifolia using high-performance liquid and thin layer chromatography analysis with tandem mass spectrometry characterization". Separation Science Plus. 5 (8): 378–392. doi:10.1002/sscp.202200048. S2CID 249304214.
  5. ^ Adib, Mohiminul; Islam, Rashedul; Ahsan, Monira; Rahman, Arifur; Hossain, Mahmud; Rahman, Md Mustafizur; Alshehri, Sultan M.; Kazi, Mohsin; Mazid, Md Abdul (2021). "Cholinesterase inhibitory activity of tinosporide and 8-hydroxytinosporide isolated from Tinospora cordifolia: In vitro and in silico studies targeting management of Alzheimer's disease". Saudi Journal of Biological Sciences. 28 (7): 3893–3900. doi:10.1016/j.sjbs.2021.03.063. PMC 8241625. PMID 34220245.
  6. ^ Pathak, Ashish K.; Jain, Dharam C.; Sharma, Ram P. (1995). "Chemistry and Biological Activities of the Genera Tinospora". International Journal of Pharmacognosy. 33 (4): 277–287. doi:10.3109/13880209509065379.
Allikas: http://en.wikipedia.org/wiki/Tinosporide
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