Tabasco is a Mexican state.

Tabasco may also refer to:

• Tabasco pepper, chili pepper
• Tabasco sauce, sauce made in part from the peppers

• Tabasco, Francisco Z. Mena
• Tabasco, José María Morelos
• Tabasco, Las Margaritas
• Tabasco, Zacatecas
• Tabasco River, Mexico
• Tabasco (former state), a Chontal Maya Nation

• Tabasco, New York, a hamlet
• Tobasco, Ohio, an unincorporated community
• Tabasco Creek, Alaska

• Tabasco mud turtle
• Burlesque Opera of Tabasco by George Whitefield Chadwick
• Simona Tabasco (born 1994), Italian actress