"Sweetest Thing" is a 1987 song by Irish rock band U2.

Sweetest Thing or The Sweetest Thing may also refer to:

• "The Sweetest Thing (I've Ever Known)", a 1975 song performed by Juice Newton and rereleased as a single in 1981
• "The Sweetest Thing" (Carlene Carter song), 1991
• "The Sweetest Thing" (Refugee Camp All Stars song), 1997
• "Sweetest Thing", a 2000 song by The Cranberries on Bury the Hatchet
• "The Sweetest Thing", a song by Camera Obscura from the 2009 album My Maudlin Career

• The Sweetest Thing (film), a 2002 American romantic comedy film directed by Roger Kumble and written by Nancy Pimental
• "The Sweetest Thing", an episode from the Nick Jr. girls' animated TV show Shimmer and Shine
• "The Sweetest Thing", an episode from the TV series Kavanagh QC
• "The Sweetest Thing", an episode from the TV series Persona
• "The Sweetest Thing", an episode from the TV series Pennies from Heaven
• "The Sweetest Thing", an episode from the cooking TV series The Taste

• All pages with titles containing Sweetest Thing
• "Love Is the Sweetest Thing", a 1932 song written by Ray Noble and performed with his orchestra and Al Bowlly, covered many times