Streptomyces rimosus is a bacterium species in the genus Streptomyces.
It was isolated from a soil sample in 1950 by A. C. Finlay et al., who isolated terramycin (earth fungus), later called oxytetracycline, from it.[1]
Uses
The antibiotics oxytetracycline and tetracycline are produced in cultures of S. rimosus. Paromomycin has also been isolated from cultures of S. rimosus.
Polyketide synthesis
Streptomyces rimosus's oxytetracycline polyketide synthase acyl carrier protein differs from most ACPs by having a C-terminus extension.[2]
References
- ^ A. C. Finlay, G. L. Hobby, S. Y. P'an, P. P. Regna, J. B. Routien, D. B. Seeley, G. M. Shull, B. A. Sobin, I. A. Solomons, J. W. Vinson, and J. H. Kane: Terramycin, a New Antibiotic, Science 111: 85 (27 January 1950) doi/10.1126/science.111.2874.85.a
- ^ White, Stephen W.; Zheng, Jie; Zhang, Yong-Mei; Rock, Charles O. (2005). "The Structural Biology of Type II Fatty Acid Biosynthesis". Annual Review of Biochemistry. 74 (1). Annual Reviews: 791–831. doi:10.1146/annurev.biochem.74.082803.133524. ISSN 0066-4154. PMID 15952903. (COR ORCID 0000-0001-8648-4189).
External links
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