Stearoyl-CoA is a coenzyme involved in the metabolism of fatty acids.[1] Stearoyl-CoA is an 18-carbon long fatty acyl-CoA chain that participates in an unsaturation reaction. The reaction is catalyzed by the enzyme stearoyl-CoA desaturase, which is located in the endoplasmic reticulum.[2] It forms a cis-double bond between the ninth and tenth carbons within the chain to form the product oleoyl-CoA.[3]
References
- ^ Ntambi, J. M. (2002). "Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity". Proceedings of the National Academy of Sciences. 99 (17): 11482–11486. Bibcode:2002PNAS...9911482N. doi:10.1073/pnas.132384699. ISSN 0027-8424. PMC 123282. PMID 12177411.
- ^ Ntambi, James (2013). Stearoyl-CoA Desaturase Genes in Lipid Metabolism. Springer. ISBN 978-1-4614-7969-7.
- ^ Igal, R. Ariel (December 2016). "Stearoyl CoA desaturase-1: New insights into a central regulator of cancer metabolism". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861 (12): 1865–1880. doi:10.1016/j.bbalip.2016.09.009. PMID 27639967.
Bibliography
- Miyazaki, M. (2000). "The Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1". Journal of Biological Chemistry. 275 (39): 30132–30138. doi:10.1074/jbc.M005488200. PMID 10899171.
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