In enzymology, a shikimate O-hydroxycinnamoyltransferase (EC 2.3.1.133) is an enzyme that catalyzes the chemical reaction

4-coumaroyl-CoA + shikimate CoA + 4-coumaroylshikimate

Thus, the two substrates of this enzyme are 4-coumaroyl-CoA and shikimate, whereas its two products are CoA and 4-coumaroylshikimate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase. This enzyme is also called shikimate hydroxycinnamoyltransferase. This enzyme participates in phenylpropanoid biosynthesis.

• Strack D, Keller H, Weissenbock G (1987). "Enzymatic-synthesis of hydroxycinnamic acid-esters of sugar acids and hydroaromatic acids by protein preparations from rye (Secale cereale) primary leaves". J. Plant Physiol. 131: 61–73.
• Ulbrich B, Zenk MH (1980). "Partial purification and properties of p-hydroxycinnamoyl-CoA:shikimate-p-hydroxycinnamoyl transferase from higher plants". Phytochemistry. 19 (8): 1625–1629. doi:10.1016/S0031-9422(00)83782-6.