Santo is a masculine given name which may refer to:

• Santo Biasatti (born 1943), Argentine journalist
• Santo Cilauro (born 1961), Australian comedian, actor, and television producer
• Santo Condorelli (born 1995), Italian swimmer
• Santo Farina, of the rock and roll duo Santo & Johnny
• Santo Jeger (1898–1953), British politician
• Santo Loquasto (born 1944), American production, set and costume designer
• Santo Mazzarino (1916–1987), Italian historian
• Santo Santoro (born 1956), Australian politician
• Santo Stephens (born 1969), American football player
• Santo Trafficante Jr. (1914–1987), American Mafia boss, head of the Trafficante crime family
• Santo Trafficante Sr. (1886–1954), Sicilian-born mobster, father of the above
• Santo Versace (born 1944), Italian businessman and politician

• Santo Vaccarro (Rockslide), a hero appearing in X-Men comics