San Domenico may refer to:

• Dominic de Guzmán (1170-1221), Spanish priest and founder of the Dominican Order
• San Domenico di Sora (951-1031), Italian abbot, patron saint of Villalago

• San Domenico, Arezzo (Basilica), Italy
• San Domenico (Basilica), Bologna, Italy
• San Domenico, Casale Monferrato, Italy
• San Domenico, Cortona, Italy
• San Domenico, Cosenza, Italy
• San Domenico, Cremona, Italy (no longer standing)
• San Domenico, Cagli, Italy
• Convent of San Domenico, Fiesole, Italy
• San Domenico, Gubbio, Italy
• San Domenico Maggiore, Naples, Italy
• San Domenico, Noto, Italy
• San Domenico, Orvieto, Italy
• San Domenico, Palermo, Italy
• San Domenico, Penne, Italy
• San Domenico, Perugia, Italy
• San Domenico (Pisa), Italy
• San Domenico, Pistoia, Italy
• San Domenico, Prato, Italy
• Santi Domenico e Sisto, Rome, Italy
• Basilica of San Domenico, Siena, Italy
• San Domenico Convent, Taormina in Taormina, Sicily, Italy
• San Domenico, Val di Noto, Italy
• San Domenico, Karaköy in Istanbul, Turkey

• Lago di San Domenico, L'Aquila, Italy
• San Domenico School, San Anselmo, California
• San Domenico (horse), Australian racehorse

• St Dominic (disambiguation)
• Santo Domingo (disambiguation)