Samos is a Greek island in the Aegean Sea.

Samus may also refer to:

• Samus Aran, the protagonist of Nintendo's Metroid video game series
• Samus (sponge), a genus of sea sponges
• Samus, the Dacian name of the Someș River
• Samus (rural locality), a rural locality in Tomsk Oblast, Russia
• Samus (poet) (≈183 BCE), Macedonian poet
• SAMUS: South African Music Studies, a peer-reviewed academic journal, and the official journal of the South African Society for Research in Music (SASRIM)
• Sammus (born 1986), rapper from Ithaca, New York