Samuel Clark or Clarke may refer to:

• Samuel Clark (minister) (1727–1769), English minister
• Samuel Clark (New York and Michigan politician) (1800–1870), American politician from New York and Michigan
• Samuel Reed Clark (1826–?), American politician from Wisconsin
• Samuel M. Clark (1842–1900), American politician from Iowa
• Samuel Clark (rugby union) (1857–1947), Welsh international rugby player
• Samuel Findlay Clark (1909–1998), Canadian soldier
• Samuel J. Clark, American demographer
• Samuel Kelly Clark (1924–2006), American mechanical engineer known for work in tire mechanics
• S. D. Clark (Samuel Delbert Clark, 1910–2003), Canadian sociologist
• Sam Clark (born 1987), Australian actor and singer-songwriter

• Samuel Clarke (minister) (1599–1683), English clergyman and Puritan biographer
• Samuel Clarke (annotator) (1626–1701), English Nonconformist clergyman known as an assiduous annotator of the Bible
• Samuel Clarke (dean of Clonmacnoise), Anglican priest in Ireland during the 17th century
• Samuel Clarke (1675–1729), English philosopher and Anglican clergyman
• Samuel Clarke of St Albans (1684–1750), English Nonconformist pastor and theological writer
• Samuel Asahel Clarke (1827–1909), Oregon poet, journalist, and historian.
• Samuel Clarke (Canadian politician) (1853–?), Canadian merchant and politician

• Sam Clarke (motorcyclist) (born 1996), Australian motorcycle racer
• Sir Samuel Clarke, 1st Baronet (died 1719) of the Clarke baronets