Sampath is a given name and surname, meaning prosperity or wealth in Hindu/Sanskrit.

• K. V. Sampath Kumar (1956/1957–2021), Indian newspaper editor
• P. Sampath Kumar, Indian politician
• P. A. Sampath Kumar, Indian Priest
• R. Sampath Raj (born 1969), Indian politician
• Sampath Amaratunge (born 1964), Sri Lankan academic and administrator
• Sampath Kumar (1950–2009), Indian actor known by his stage name Vishnuvardhan
• Sampath Kumar D.Y. (1927–1999), Indian dancer and choreographer
• Sampath Kuttymani (born 1986), Indian footballer
• Sampath Lakmal de Silva (c. 1982–2006), Sri Lankan journalist
• Sampath Nandi (born 1980), Indian film director
• Sampath Parthasarathy
• Sampath Perera (born 1965), Sri Lankan football manager
• Sampath Perera (cricketer) (born 1982), Sri Lankan cricketer
• Sampath Raj (born 1968), Indian actor
• Sampath Ram, Indian actor
• Sampath Tennakoon (1959–2021), Sri Lankan actor

• A. G. Sampath, Indian politician
• Anirudhan Sampath (born 1962), Indian politician
• Balaji Sampath (born 1973), Indian educationist and social activist
• Chaminda Sampath, Sri Lankan politician
• Chiki Sampath (1920–1990), Trinidadian cricketer
• E. V. K. Sampath (c. 1926–1977), Indian politician
• Janaka Sampath (born 1987), Sri Lankan cricketer
• Jai Sampath (born 1984), Indian actor
• Kuppuswami Sampath, Indian footballer
• M. C. Sampath, Indian politician
• Nanjil Sampath, Indian politician
• Nuwan Sampath (born 1996), Sri Lankan cricketer
• Ram Sampath (born 1977), Indian musical artist
• Roland Sampath (born 1957), Trinidadian cricketer
• Shanaka Sampath (born 1991), Sri Lankan cricketer
• Srinivasan Sampath (born 1961), Indian electrochemist, nanotechnologist and professor
• Suranga Sampath, Sri Lankan blind cricketer
• Thusara Sampath (born 1974), Sri Lankan cricketer
• Tillakaratne Sampath (born 1982), Sri Lankan cricketer
• V. S. Sampath (born 1950), 18th Chief Election Commissioner of India
• Vikram Sampath, Indian historian

• Mavinakere Cheluvayyangar (1904–1983), Indian film actor better known by his stage name Sampath