In enzymology, a ribose-5-phosphate adenylyltransferase (EC 2.7.7.35) is an enzyme that catalyzes the chemical reaction

ADP + D-ribose 5-phosphate phosphate + ADP-ribose

Thus, the two substrates of this enzyme are ADP and D-ribose 5-phosphate, whereas its two products are phosphate and ADP-ribose.

This enzyme belongs to the family of transferases, specifically ones transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ADP:D-ribose-5-phosphate adenylyltransferase. Other names in common use include ADP ribose phosphorylase, and adenosine diphosphoribose phosphorylase.

• Evans WR, San Pietro A (1966). "Phosphorolysis of adenosine diphosphoribose". Arch. Biochem. Biophys. 113 (1): 236–44. doi:10.1016/0003-9861(66)90178-0. PMID 4287446.
• Stern AI, Avron M (1966). "An adenosine 5'-diphosphate ribose:orthophosphate adenylyltransferase from Euglena gracilis". Biochim. Biophys. Acta. 118 (3): 577–91. doi:10.1016/s0926-6593(66)80099-1. PMID 5970863.