Region 2 or Region II may refer to:
- Region 2, Northwest Territories (Canadian census)
- The Midwest of the US (American census)
- Former Region 2 (Johannesburg), an administrative district in Johannesburg, South Africa, from 2000 to 2006
- Antofagasta Region, Chile
- Cagayan Valley (Region II), Philippines
- ITU Region 2, consisting of the Americas
- One of the DVD regions
- One of the health regions of Canada, managed by Horizon Health Network
- One of the regions of Iran
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