A puffball is a type of fungi.
Puffball may also refer to:
- Puffball (novel), a 1980 supernatural novel by Fay Weldon
- Puffball (film), a 2007 British film adaptation of the novel
- Puffball Collective, a Marvel Comics group
- Puffball Islands, a group of Antarctic islands
See also
- Caenocara, a beetle genus, some species of which are known as puffball beetles
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