Prysock is a surname. Notable people with the surname include:

• Arthur Prysock (1924 or 1929–1997), American jazz and R&B singer
• Ephesians Prysock, American football player
• Wilburt Red Prysock (1926–1993), American R&B tenor saxophonist

See also:

• Arthur Prysock (Jeeves character), minor character in the Jeeves and Wooster episode "Introduction on Broadway"
• Arthur Prysock and Count Basie, studio album by Arthur Prysock and Count Basie