Prunetin is an O-methylated isoflavone, a type of flavonoid. It has been isolated for the first time by Finnemore in 1910 in the bark of Prunus emarginata (the Oregon cherry).[1] Prunetin isolated from pea roots can act as an attractant for Aphanomyces euteiches zoospores.[2] It is also an allosteric inhibitor of human liver aldehyde dehydrogenase.[3]

Prunetin can lower blood pressure of spontaneously hypertensive rats and relax isolated rat aortic rings through calcium channel block mechanisms in vessel smooth muscles.[4]

Glycosides

See also

References

  1. ^ Shriner, R. L.; Hull, Clarence J. (1945). "Isoflavones. III. The Structure of Prunetin and a New Synthesis of Genistein1". The Journal of Organic Chemistry. 10 (4): 288–291. doi:10.1021/jo01180a006.
  2. ^ Yokosawa, Ryozo; Kuninaga, Shiro; Sekizaki, Harua (1986). "Aphanomyces euteiches zoospore attractant isolated from pea root; prunetin". Ann. Phytopath. Soc. Japan. 52 (5): 809–816. doi:10.3186/jjphytopath.52.809.
  3. ^ Sheikh, S.; Weiner, H. (1997). "Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin". Biochemical Pharmacology. 53 (4): 471–478. doi:10.1016/s0006-2952(96)00837-4. PMID 9105397.
  4. ^ Kim, Bumjung; Jo, Cheolmin; Choi, Ho-Young; Lee, Kyungjin (2018). "Prunetin Relaxed Isolated Rat Aortic Rings by Blocking Calcium Channels". Molecules. 23 (9): 2372. doi:10.3390/molecules23092372. PMC 6225200. PMID 30227625. This article incorporates text from this source, which is available under the CC BY 4.0 license.
  5. ^ Pei Cheng Zhang, Ying Hong Wang, Xin Liu, Xiang Yi, Ruo Yun Chen and De Quan Yu (2002). "Conformational Study of 8-C-glucosyl-prunetin by Dynamic NMR Spectroscopy" (PDF). Chinese Chemical Letters. 13 (7): 645–648. Archived from the original (PDF) on 2011-07-07. Retrieved 2010-02-26.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Allikas: http://en.wikipedia.org/wiki/Prunetin
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