The Polytechnic University of Nicaragua (Spanish: Universidad Politecnica de Nicaragua, UPOLI) is a university in Managua, Nicaragua. It was founded in 1967.

The university has six schools:

• School of Administration, Commerce and Finance
• School of Law
• School of Design
• School of Nursing
• School of Engineering
• Music Conservatory

UPOLI International (Spanish: Universidad Politecnica de Nicaragua Internacional) is the online division. UPOLI International was established in 2013 by Tomás H. Téllez Ruiz, MSc., of the Polytechnic University of Nicaragua and Ricky M. Andrew, MBA.

• Education in Nicaragua
• List of universities in Nicaragua

• Official website (in Spanish)
• UPOLI International website

12°08′13″N 86°13′11″W / 12.13703°N 86.21976°W / 12.13703; -86.21976