Pollexfen is a British, South Devon surname associated and may refer to:

• Henry Pollexfen (1632–1691), British judge and politician
• John Pollexfen (1636–1715), British merchant, political economist, and Justice-of-the-Peace
• Jack Pollexfen (1908–2003), US screenwriter and film producer
• Susan Pollexfen (1841-3–1900), wife of Irish artist John Butler Yeats

• Edmund Pollexfen Bastard (1784–1838), British Tory politician
• John Pollexfen Bastard (1756–1816), British Tory politician and colonel of the East Devonshire Militia