Pilot Knob may refer to:

• Pilot Knob, Missouri
• Pilot Knob, New York
• Pilot Knob, Texas
• Pilot Knob, Wisconsin
• Pilot Knob Station, a former stage station of the Butterfeild Overland Mail near Andrade, California
• Pilot Knob Township, Washington County, Illinois

• Pilot Knob (Fresno County, California)
• Pilot Knob (Imperial County, California)
• Pilot Knob (Colorado), a summit in the San Juan Mountains of Colorado
• Pilot Knob, a high mountain summit in the Elkhead Mountains of Colorado
• Pilot Knob State Park, near Forest City, Iowa
• Pilot Knob State Nature Preserve, Powell County, Kentucky
• Oheyawahi-Pilot Knob, on the National Register of Historic Places listings in Dakota County, Minnesota
• Pilot Knob (Iron County, Missouri), Iron, Missouri
• Pilot Knob (Austin, Texas)
• Pilot Knob Mountain, a tank gunnery range at Fort Hood, Texas

• Battle of Pilot Knob, in Missouri
• Camp Pilot Knob, a U.S. Army camp in Riverside County, California
• Pilot Butte (disambiguation)
• Pilot Hill (disambiguation)
• Pilot Mountain (disambiguation)
• Pilot Peak (disambiguation)