The enzyme phenylserine aldolase (EC 4.1.2.26) catalyzes the chemical reaction

L-threo-3-phenylserine glycine + benzaldehyde

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming). This enzyme is also called L-threo-3-phenylserine benzaldehyde-lyase. It employs one cofactor, pyridoxal phosphate.

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1V72.

• BRUNS FH, FIEDLER L (1958). "Enzymatic cleavage and synthesis of L-threo-beta-phenylserine and L-erythro-beta-Phenyldrine". Nature. 181 (4622): 1533–4. Bibcode:1958Natur.181.1533B. doi:10.1038/1811533a0. PMID 13566053. S2CID 4277787.