Peter or Pete Holmes may refer to:

• Peter Holmes (1675–1732), Irish High Sheriff and MP in the Irish House of Commons
• Peter Holmes (1731–1802), Irish High Sheriff and MP in the Parliament of Ireland
• Peter Holmes (businessman) (1932–2002), British businessman
• Pete Holmes (politician) (born 1956), Seattle City Attorney
• Pete Holmes (born 1979), American stand-up comedian, actor, writer, podcaster, and cartoonist
• Peter Holmes (footballer) (born 1980), English footballer