Paul-Antoine is a French masculine given name. It may refer to:
- Paul Antoine Bien-Aimé, Minister of the Interior and Territorial Collectivity of Haiti
- Paul Antoine Dubois (1795-1871), French obstetrician
- Paul-Antoine Giguère (1910–1987), Canadian academic and chemist
- Paul-Antoine Léonard de Villefeix (1728–?), French Dominican priest
- Paul Antoine Fleuriot de Langle (1744–1787), French vicomte, académicien de marine, naval commander and explorer
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