P80 may refer to:
Automobiles
- BMW P80, a family of Formula One engines
- Toyota Starlet (P80), a Japanese car
- Volvo P80 platform, a Swedish mid-size automobile platform
- WM P80, a French prototype racing car
Other vehicles
- P80 (rocket stage), a rocket engine
- INS Kavaratti (P80), a corvette of the Indian Navy
- Lockheed P-80 Shooting Star, an American jet fighter
- Pottier P.80, a French sport aircraft
Other uses
- Nikon Coolpix P80, a digital camera
- P80, a national road of Latvia
- Pestivirus NS3 polyprotein peptidase, an enzyme
- p80, a subunit of the protein Katanin
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