Oswego may refer to:

• Oswego, Illinois, a village in Kendall County
• Oswego, Indiana, an unincorporated place in Kosciusko County
• Oswego, Kansas, a city in Labette County
• Oswego, Mississippi, an unincorporated community
• Oswego, Montana, a village in Valley County
• Oswego River (New Jersey), a tributary of the Wading River
• Oswego, South Carolina, a census-designated place in Sumter County
• Lake Oswego, Oregon, a city in northwest Oregon
• Oswego Lake, a lake in Lake Oswego, Oregon
• In New York:
  • Oswego, New York, a city in Oswego County
    • State University of New York at Oswego, a public university
    • Fort Oswego, which occupied the same site
  • Oswego County, New York
  • Oswego River (New York), a tributary of Lake Ontario
  • Oswego (town), New York, a town in Oswego County

• Monarda didyma (Oswego Tea), a flower and an herb, native to North America

• Owego (disambiguation)