Orsi is a surname of Italian origin, and may refer to the following people:

• Adolfo Orsi (1888–1972), Italian industrialist, owner of Maserati
• Anaïs Orsi, climate scientist
• Benedetto Orsi (died 1680), Italian painter
• Carlo Orsi (fl. 1884–1894), Italian painter and sculptor
• Checco and Ludovico Orsi, brothers who led the assassination of Girolamo Riario in 1488
• Clodomil Orsi, Brazilian football executive, Corinthians Chairman in 2007
• Dan Orsi (born 1992), Scottish footballer
• Danilo Orsi-Dadomo (born 1996), British footballer
• Favio Orsi (born 1974), Argentine football player and manager
• Federico Ferrari Orsi (1886-1942), Italian general in the Royal Army during World War II
• Fernando Orsi (born 1959), Italian football manager and former player
• Franco Orsi (born 1966), Italian politician
• Ginger Orsi (born 1984), American child actress and singer, sister of Leigh Ann Orsi
• Giuseppe Agostino Orsi (1692–1761), Italian cardinal, theologian, and ecclesiastical historian
• Giuseppe Orsi (born 1945), Italian industrialist
• Giuseppe Orsi (1885-1911), Italian army officer died in Sciara Sciat, awarded posthumously the Gold Medal of Military Valour
• Guillermo Orsi (born 1946), Argentine journalist and novelist
• Hoover Orsi (born 1978), Brazilian race car driver
• John Orsi (1908–1978), American football player
• Kalvin Orsi (born 1997), Scottish football winger
• Leigh Ann Orsi (born 1981), American actress and dancer, sister of Ginger Orsi
• Lelio Orsi (1508/1511–1587), Italian Renaissance painter
• Marco Orsi (born 1990), Italian swimmer
• Micaela Orsi (born 1993), Uruguayan model
• Ni Orsi Jr. (born 1944), American alpine skier
• Paolo Orsi (1859–1935), Italian archaeologist and classicist
• Phil Orsi (born 1939), American singer, songwriter, producer and musician
• Prospero Orsi (1560s-1630s), Italian painter of the late-Mannerist and early-Baroque period
• Raimundo Orsi (1901–1986), Argentinian-Italian footballer
• Robert Orsi (born 1953), American scholar
• Rocío Orsi (1976-2014), Spanish philosopher and professor
• Romeo Orsi Italian industrialist and manufacturer of wind instruments, founder of Orsi Instrument Company
• Tranquillo Orsi (1771–1845), Italian painter, scenographer, and architect
• Viktoria Orsi Toth (born 1990), Italian beach volleyball player
• Yamandú Orsi (born 1967), president of Uruguay

Orsi is also a short form of female Hungarian first name Orsolya and may refer to:

• Orsi Kocsis (born 1984), Hungarian model
• Orsi Tóth (born 1981), Hungarian actress

• Orsi Instrument Company (est. 1836), a clarinet maker
• Palazzo Orsi Mangelli, a Baroque architecture palace in Forlì, Italy
• Orsi Pietro & Figlio, or Orsi, Italian maker of agricultural machines
• Orsi Point, a headland in Malta on which Fort Ricasoli was built
• Orsi Tower and Battery, a tower and battery on the headland (destroyed)
• D'Orsi
• Orsy (disambiguation)