The enzyme orsellinate decarboxylase (EC 4.1.1.58) catalyzes the chemical reaction

2,4-dihydroxy-6-methylbenzoate orcinol + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2,4-dihydroxy-6-methylbenzoate carboxy-lyase (orcinol-forming). This enzyme is also called orsellinate carboxy-lyase.^{[citation needed]}

• Pettersson G, Lahermo P, Tummavuori J (1965). "An orsellinic acid decarboxylase isolated from Gliocladium roseum". Acta Chem. Scand. 19: 2013–2021. doi:10.3891/acta.chem.scand.19-2013.