OSD may refer to:

• Ocean Science Discussions, the discussion and review section of the journal Ocean Science
• Optimal shape design, a part of the field of optimal control theory
• Oral sedation dentistry, the oral administration of sedatives to facilitate dental procedures
• Oral solid dose, a form of oral administration of medication
• Osgood–Schlatter disease, an inflammation of the growth plate at the tibial tuberosity which occurs mostly in teenage boys

• Object storage device, computer data storage device that manages data as objects
• Online standards development, platform for the development of standards of the International Electrotechnical Commission
• On-screen display, a feature of visual devices like VCRs and DVD players that displays program, position, and setting data on a connected TV or computer display
• Open Source Definition, criteria used by the Open Source Initiative to determine whether or not a software license can be considered open source
• OpenSearch Description document, an XML file format that identifies and describes a search engine
• Operating System Deployment, a component of Microsoft's System Center Configuration Manager product
• Orthotropic steel deck, a roofing and bridging technique

• Åre Östersund Airport, Sweden, IATA airport code
• Office of the Secretary of Defense, the principal staff of the United States Secretary of Defense
• Officer on Special Duty, a Bangladeshi, Indian, and Pakistani civil service officer
• Oklahoma School for the Deaf, a K-12 residential school for the deaf or hard-hearing students
• Olympia School District, a school district in Olympia, Washington
• One Shot Deal, a live album by Frank Zappa posthumously released in 2008
• Oregon School for the Deaf
• Overseas Surveys Directorate, the United Kingdom's central survey and mapping organisation for British colonies and protectorates 1984–1991
• Oxnard Elementary School District, a school district in Oxnard, California