In enzymology, a nucleoside phosphoacylhydrolase (EC 3.6.1.24) is an enzyme that catalyzes the chemical reaction

Hydrolyses mixed phospho-anhydride bonds

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is nucleoside-5'-phosphoacylate acylhydrolase.

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