Necatorin is a highly mutagenic chemical compound with the molecular formula C15H8N2O3. It is found in some mushrooms including Lactarius necator (ugly milk-cap), from which it was first isolated and characterized.[2] It tests positive in the Ames test, an assay for mutagenicity.[3] Crude extracts of L. necator are also highly mutagenic in a bacterial test system, and this effect it attributed to necatorin.[4]

Necatorin is present in L. necator at concentrations of 3 to 20 mg/kg, and blanching the mushroom can reduce it to about 25% of its original amount.[5] In boiling water, the chemical compound is stable except under acidic conditions (pH = 5).[5]

References

  1. ^ "Necatorine". Human Metabolome Database.
  2. ^ Suortti, Tapani; von Wright, Atte; Koskinen, Ari (1983). "Necatorin, a highly mutagenic compound from Lactarius necator". Phytochemistry. 22 (12): 2873–2874. Bibcode:1983PChem..22.2873S. doi:10.1016/S0031-9422(00)97723-9.
  3. ^ von Wright, Atte; Suortti, Tapani (1983). "Preliminary characterization of the mutagenic properties of 'necatorin', a strongly mutagenic compound of the mushroom Lactarius necator". Mutation Research Letters. 121 (2): 103–106. doi:10.1016/0165-7992(83)90107-0. PMID 6348529.
  4. ^ Grüter, A.; Friederich, U.; Würgler, F.E. (1991). "The mutagenicity of edible mushrooms in a histidine-independent bacterial test system". Food and Chemical Toxicology. 29 (3): 159–165. doi:10.1016/0278-6915(91)90033-4. PMID 2032657.
  5. ^ a b Suortti, T. (1984). "Stability of necatorin, a highly mutagenic compound from Lactarius necator mushroom". Food and Chemical Toxicology. 22 (7): 579–581. doi:10.1016/0278-6915(84)90229-1. PMID 6547686.
Allikas: http://en.wikipedia.org/wiki/Necatorin
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