The Most Precious Blood refers to the Eucharist, a Christian rite.

Most Precious Blood can also refer to:

• The Blood of Christ, the blood shed by Jesus Christ, primarily on the Cross
  • Archconfraternity of the Most Precious Blood
  • Church of the Most Precious Blood (Manhattan)
  • Church of the Most Precious Blood, Southwark, London
  • Scapular of the Most Precious Blood
  • Most Precious Blood Roman Catholic Church, Rectory and Parochial School

• Most Precious Blood (band), an American band
• Most Precious Blood, a 1998 album by Indecision

• Precious Blood Catholic Church (disambiguation)