Mississippi Delta may refer to:

• Mississippi Alluvial Plain, the entire alluvial plain of the Mississippi River, from the river mouth to southern Illinois
  • Mississippi embayment, the upper two-thirds of the Mississippi Alluvial Plain, between central Louisiana and southern Illinois
    • Mississippi Delta, a distinct cultural area in northwest Mississippi state; part of the Mississippi embayment
  • Mississippi River Delta, the confluence of the Mississippi River with the Gulf of Mexico in Louisiana
• Mississippi Delta AVA [not outlined on the inset map], an American Viticultural Area including portions of Louisiana, Mississippi, and Tennessee
• "Mississippi Delta" (song), a 1967 song by Bobbie Gentry

• Arkansas Delta
• Delta, Mississippi, a ghost town in the region known as the "Mississippi Delta"