In molecular biology mir-938 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-938 and the TGF-β pathway
miR-938 has been found to directly target the SMAD3 gene, which encodes the main downstream TGF-β polypeptide SMAD3. This microRNA is overexpressed in non-functioning pituitary adenomas (NFPAs) compared with normal pituitary tissue.[1] Downregulation of TGF-β signalling is likely to play a role in the regulation of signalling pathways in NFPA tumorigenesis, thus also implicating SMAD3 and miR-938.
See also
References
- ^ Butz H, Likó I, Czirják S, Igaz P, Korbonits M, Rácz K, et al. (2011). "MicroRNA profile indicates downregulation of the TGFβ pathway in sporadic non-functioning pituitary adenomas". Pituitary. 14 (2): 112–24. doi:10.1007/s11102-010-0268-x. PMID 21063788. S2CID 20173229.
Further reading
- Arisawa, T.; Tahara, T.; Shiroeda, H.; Matsue, Y.; Minato, T.; Nomura, T.; Yamada, H.; Hayashi, R.; Saito, T.; Matsunaga, K.; Fukuyama, T.; Hayashi, N.; Otsuka, T.; Fukumura, A.; Nakamura, M.; Shibata, T. (2012). "Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3′-UTR, influence susceptibility to gastric cancer". Human Immunology. 73 (7): 747–752. doi:10.1016/j.humimm.2012.04.011. PMID 22537748.
- Mi, X.; He, H.; Deng, Y.; Levin, A. M.; She, J. X.; Mi, Q. S.; Zhou, L. (2011). "Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes". Diabetology & Metabolic Syndrome. 3 (1): 27. doi:10.1186/1758-5996-3-27. PMC 3215172. PMID 22014115.
External links
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