Mindfuck may refer to:

• A synonym for mind games for a manipulative abusive purpose.
• Operation Mindfuck, a principle of discordianism
• Incredible Expanding Mindfuck, an experimental music group founded by Steven Wilson
  • I.E.M. (album), eponymous debut album of said group
• "Mindfuck", a song by Ween, from their 1986 album The Crucial Squeegie Lip
• "Mindfuck (A New Equation)", a song by The Coup, from their 2006 album Pick a Bigger Weapon
• Mindfuck, a supporting character in Adam Warren's Empowered.
• "Mindfuck", a 2019 book by Christopher Wylie about the Facebook–Cambridge Analytica data scandal
• MINDF*CK, Dutch television show presented by Victor Mids