N-Methylpiperazine is a heterocyclic organic compound.

Uses

N-Methylpiperazine is a common building block used in organic synthesis.[2] For example, N-methylpiperazine is used in the manufacture of various pharmaceutical drugs including cyclizine,[3] meclizine, and sildenafil.

The lithium salt, lithium N-methylpiperazide, is used as a reagent in organic synthesis for protection of aryl aldehydes.[4]

Synthesis

Industrially, N-methylpiperazine is produced by reacting diethanolamine and methylamine at 250 bar and 200 °C.[5][6]

References

  1. ^ a b "1-Methylpiperazine". Chemistry Dashboard. Environmental Protection Agency.
  2. ^ "1-methylpiperazine". European Chemicals Agency.
  3. ^ Vardanyan, Ṛuben & Hruby, Victor J. Synthesis of Essential Drugs. p. 226.{{cite book}}: CS1 maint: multiple names: authors list (link)
  4. ^ Comins, Daniel L.; Joseph, Sajan P. (2001). "Lithium N-Methylpiperazide". Encyclopedia of Reagents for Organic Synthesis. doi:10.1002/047084289X.rl128. ISBN 0471936235.
  5. ^ US 4845218, "Preparation of N-Methylpiperazine", issued 1989-07-04 
  6. ^ "Catalytic synthesis of N-methylpiperazine from diethanolamine and methylamine by cyclodehydration reaction" (PDF). Indian Journal of Chemical Technology. 1 (November): 359–360. 1994.
Allikas: http://en.wikipedia.org/wiki/Methylpiperazine
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