7-Methylguanosine (m7G) is a modified purine nucleoside. It is a methylated version of guanosine and when found in human urine, it may be a biomarker of some types of cancer. In the RNAs, 7-methylguanosine have been used to study and examine the reaction evolving methylguanosine. It also participates in the formation of 5'-cap that stabilizes mRNA and prevents its degradation by 5' exonucleases.[1][2]
See also
- m7G(5')pppN diphosphatase
- METTL1
- Messenger RNA decapping
- 23S rRNA (guanine2445-N2)-methyltransferase
- 16S rRNA (guanine527-N7)-methyltransferase
References
- ^ Furuichi, Yasuhiro (2015). "Discovery of m7G-cap in eukaryotic mRNAs". Proceedings of the Japan Academy, Series B. 91 (8): 394–409. doi:10.2183/pjab.91.394. PMC 4729855. PMID 26460318.
- ^ Reynaud, C; Bruno, C; Boullanger, P; Grange, J; Barbesti, S; Niveleau, A (1992). "Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies". Cancer Letters. 61 (3): 255–62. doi:10.1016/0304-3835(92)90296-8. PMID 1739950.
External links
- Metabocard for 7-Methylguanosine (HMDB01107), Human Metabolome Database, University of Alberta
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