Maximiscin is a polyketide-shikimate chemical compound isolated from Tolypocladium that shows tumor growth suppression in an animal model.[1] The discovery of maximiscin was the result of a citizen scientist crowdsourcing project by the University of Oklahoma.[2] The soil sample which yielded maximiscin was sent by a woman from Salcha, Alaska.[3]

References

  1. ^ Du, L; Robles, AJ; King, JB; Powell, DR; Miller, AN; Mooberry, SL; Cichewicz, RH (2013). "Maximiscin, a Novel Shikimate-Polyketide-NRPS Hybrid Metabolite Obtained from Tolypocladium Sp. With Potent Antitumor Activities". Planta Medica. 79 (10). doi:10.1055/s-0033-1348528.
  2. ^ Du, L; Robles, AJ; King, JB; Powell, DR; Miller, AN; Mooberry, SL; Cichewicz, RH (2013). "Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity". Angewandte Chemie International Edition in English. 53 (3): 804–9. doi:10.1002/anie.201306549. PMC 4028707. PMID 24285637.
  3. ^ Julianne Wyrick (December 5, 2013). "Crowdsourcing unearths promising anticancer compound". chemistryworld.com. Royal Society of Chemistry.


Allikas: http://en.wikipedia.org/wiki/Maximiscin
No tags for this post.