Matthew or Matt Knowles may refer to:

• Matt Knowles (born 1974), professional wrestler
• Matt Knowles (soccer) (born 1970), soccer player
• Matt Knowles (rugby league) (born 1975), rugby league footballer
• Matt William Knowles (born 1985), actor
• Mathew Knowles (born 1952), record executive, father of Beyoncé Knowles