Manuel Garcia may refer to:

• Manuel García (tenor) (1775–1832), Spanish singer and composer, father of Manuel Patricio Rodríguez García
• Manuel García (baritone) (1805–1906), Spanish singer & voice pedagogue; son of Manuel García (tenor)
• Manuel García Ferré (1929–2013), Spanish comic book artist
• Manuel García (singer-songwriter) (born 1970), Chilean singer-songwriter
• Manolo García (make-up artist) (aka Manuel García), Spanish make-up artist

• Garcí Manuel de Carbajal (died 1552), Spanish lieutenant
• Manuel García Banqueda (1803–1872), Chilean Minister of War and Navy
• Manuel García de la Huerta (fl. 1877–1878), Chilean Minister of War and Navy
• Manuel Rebollo García (born 1945), Spanish Navy admiral

• Manuel José García (1784–1848), Argentine politician, lawyer, economist and diplomat
• Manuel García (governor) (fl. 1826–1829), Spanish governor of Melilla
• Manuel García Prieto, Marquis of Alhucemas (1859–1938), Spanish prime minister
• Manuel García Pelayo (1909–1991), Spanish jurist

• Manuel García (footballer, born 1980), Argentinian football forward
• Manuel García (footballer, born 1985), Chilean football midfielder
• Manuel García (footballer, born 8 July 1988), Argentine football goalkeeper
• Manuel García (footballer, born 31 July 1988), Mexican football defender
• Manu García (disambiguation), several players

• Cocaína García (Manuel García Carranza, 1905–1995), Cuban baseball player
• Manuel García (boxer) (born 1935), Spanish Olympic boxer
• Manuel García (biathlete) (born 1955), Spanish Olympic biathlete
• Manuel García (cyclist) (born 1964), cyclist from Guam

• Manuel Pereiras García (born 1950), Cuban author and translator
• Manuel Garcia-Duran, Spanish businessman

• Manuel Garcia, Texas, a census-designated place in Starr County, Texas, United States