Macbecins are a pair of chemical compounds in the ansamycin family of antibiotics. They are designated macbecin I and macbecin II and they were first isolated from actinomycete bacteria.[1][2] Macbecin possesses antitumor properties.[1] In vitro studies have shown that macbecins are effective in the eradication of Gram-positive bacteria, fungi, and protozoa including Tetrahymena pyriformis.[1]

Structure

Macbecins have an unusual macrocyclic lactam structure. The two variants, macbecin I and II, correspond to the oxidized 1,4-benzoquinone and reduced hydroquinone, respectively.[2]

Mechanism of action

Macbecins mechanism of action is in part due to heat shock protein Hsp90 protein inhibition.[3]

References

  1. ^ a b c Tanida S, Hasegawa T, Higashide E (February 1980). "Macbecins I and II, new antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activities". J. Antibiot. 33 (2): 199–204. doi:10.7164/antibiotics.33.199. PMID 7380729.
  2. ^ a b Muroi M, Izawa M, Kosai Y, Asai M (February 1980). "Macbecins I and II, new antitumor antibiotics. II. Isolation and characterization". J. Antibiot. 33 (2): 205–12. doi:10.7164/antibiotics.33.205. PMID 7380730.
  3. ^ Bohen SP (June 1998). "Genetic and Biochemical Analysis of p23 and Ansamycin Antibiotics in the Function of Hsp90-Dependent Signaling Proteins". Mol. Cell. Biol. 18 (6): 3330–9. doi:10.1128/MCB.18.6.3330. PMC 108914. PMID 9584173.
Allikas: http://en.wikipedia.org/wiki/Macbecin
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