ML-154 (NCGC-84) is a drug which acts as a selective, non-peptide antagonist at the neuropeptide S receptor NPSR.[1] In animal studies it decreases self-administration of alcohol in addicted rats, and lowers motivation for alcohol rewards, suggesting a potential application for NPS antagonists in the treatment of alcoholism.[2]

See also

References

  1. ^ Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, et al. (November 2013). "Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor". Journal of Medicinal Chemistry. 56 (22): 9045–56. doi:10.1021/jm400904m. PMC 4877059. PMID 24171469.
  2. ^ Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, et al. (June 2013). "A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats". The Journal of Neuroscience. 33 (24): 10132–42. doi:10.1523/JNEUROSCI.4742-12.2013. PMC 3682378. PMID 23761908.


Allikas: http://en.wikipedia.org/wiki/ML-154
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