Luis Rodriguez may refer to:

• Luis Rodríguez (producer) (born 1948), Spanish record producer based in Germany
• Luis J. Rodriguez (born 1954), American poet and novelist
• Luis Rodríguez (born 1978), Puerto Rican singer and songwriter known professionally as Luis Fonsi
• Luis Rodriguez, a human character on Sesame Street, played by Emilio Delgado

• Luisín Rodríguez (1910–1990) Spanish footballer, player and manager of CD Logroñés
• Luis Rodríguez (Chilean footballer) (born 1961)
• Luis Rodriguez de la Rosa (born 1979), referee in the 2009–10 CONCACAF Champions League group stage
• Luis Rodríguez (Guatemalan footballer) (born 1982), Guatemalan football player
• Luis Antonio Rodríguez (born 1985), Argentine football player
• Luis Sánchez Rodríguez (born 1988), Mexican footballer
• Luis Rodríguez (footballer, born 1991) (born 1991), Mexican football player
• Luis Eduardo Rodríguez (born 1991), Mexican football player
• Luis Rodríguez (born 1992), member of the Costa Rican team in the 2009 FIFA under-17 world cup
• Luis Rodríguez (Bolivian footballer) (born 1994), Bolivian football left-back
• Luis Rodríguez (footballer, born October 1994), Mexican football midfielder for Chiapas
• Luis Rodríguez (Colombian footballer) (born 1995)

• Luis Rodriguez Olmo (1919–2017), Puerto Rican baseball player
• Luis Manuel Rodríguez (1937–1996), Cuban boxer
• Luis Rodríguez (Venezuelan boxer) (born 1947), Venezuelan boxer
• Luis Rodríguez (sprinter) (born 1966), Spanish athlete
• Luis Rodríguez (volleyball) (born 1969), Puerto Rican volleyball player
• Luis Rodríguez (baseball) (born 1980), Venezuelan baseball player

• Luis Orlando Rodríguez (1912–1989), Cuban journalist, politician and interior minister and the first commentator of Radio Rebelde
• Luis Rodríguez (astronomer) (born 1948), Mexican astronomer, member of the Colegio Nacional

• Luis Miguel Rodríguez (disambiguation)
• José Luis Rodríguez (disambiguation)