This a list of notable people from the Indian city of Alappuzha, Kerala.

• Tessy Thomas - DRDO
• Itty Achudan - the major contributor of ethno-medical information for the compilation of Hortus Malabaricus
• Illiparambil Corah Chacko - geologist
• Pallithanam Luca Matthai - pioneer of kayal cultivation in Kuttanad, and former member of Sree Moolam Popular Assembly
• Sreedhara Panicker Somanath - Current Chairman of the Indian Space Research Organisation
• M. S. Swaminathan - Agronomist, Agricultural Scientist

• K. Madhu - film director, film producer, actor
• Saranya Ponvannan - actor
• Parvathy Jayaram - actor
• Mammootty - actor
• Navodaya Appachan (Chacko Punnoose) - film producer, director, and entrepreneur
• Ashokan - Malayalam film actor, 1978–
• Thoppil Bhasi - playwright, screenwriter, and film director
• Kunchako Boban - film actor
• Riaz M T - Film Actor
• Rajan P. Dev - Malayalam film actor
• Fazil - film director
• Fahad Fazil - film actor
• Chelangatt Gopalakrishnan - film critic and writer
• Kunchacko - film producer and director
• K. P. A. C. Lalitha - film actress
• Balachandra Menon - film actor, director, script writer
• Navya Nair - film actress in Malayalam, Tamil, and Kannada films
• Padmarajan - film director, script writer, story writer
• Chenganoor Raman Pillai - stage actor
• Muthukulam Raghavan Pillai - dramatist, film actor, poet
• Narendra Prasad - actor, playwright, and director
• Ratheesh - film actor
• M. G. Sreekumar - playback singer and film music director
• Sreekumaran Thampi - lyricist, director, producer, script writer
• Vayalar Sarath Chandra Varma - film lyricist
• Nedumudi Venu - film actor
• Vinayan - film director
• Saranya Mohan - film actor
• Aarsha Chandini Baiju - film actress
• Sibi Malayil - film director
• Renji Panicker - Actor, Scriptwriter, Film Director
• Mallika Sukumaran - Actress

• K. Shankar Pillai - cartoonist (Shankar)

• Eleanour Sinclair Rohde - British gardener and writer on gardening
• Joy J. Kaimaparamban - English and Malayalam author
• Ayyappa Paniker - poet
• Kavalam Narayana Panicker - poet
• Parappurath (K. E. Mathai) - novelist and short story writer
• Thakazhi Sivasankara Pillai - novelist and short story writer
• Vayalar Ramavarma- Malayalam poet and film lyricist
• K. P. Sasidharan- Malayalam writer and academic
• Lopamudra R - Malayalam Poet and Translator

• Mavelikkara Velukkutty Nair - mridangam player
• Palani Subramaniam Pillai - percussionist, played the mridangam and kanjira
• Erickavu N. Sunil - mridangam player
• Mavelikkara Prabhakara Varma - Carnatic singer
• V. Dakshinamoorthy - Music Composer, Carnatic Vocalist
• M. G. Radhakrishnan - Music Composer
• Pathiyoor Sankarankutty - Kathakali Musician

• Mathoor Govindan Kutty - Kathakali Artist

• Bhima Bhattar - founder of Bhima Jewellers at Mullakkal, Alleppey

• Justice CT Ravikumar,Judge Supreme Court of India

• V. S. Achuthanandan - former Chief Minister and current leader of opposition of Kerala
• K. R. Gowri Amma - Revenue Minister in the first Kerala LDF ministry, initiated the revolutionary land reforms in Kerala, Agriculture Minister in Kerala UDF Ministry
• A. K. Antony - Three-time Chief Minister of Kerala, Former Indian Defence Minister
• Ramesh Chennithala - politician, former Member of Parliament
• T. K. Madhavan (1885—1930) social reformer, journalist and revolutionary
• Pallithanam Luca Matthai - Former member of Sree Moolam Popular Assembly and pioneer of kayal cultivation in Kuttanad
• Kavalam Madhava Panikkar - diplomat, administrator, historian
• P. Parameswaran - director of Bharathiya Vichara Kendram and president of Vivekananda Kendram
• Vayalar Ravi - former Home minister of Kerala, Union Cabinet Minister of Overseas Indian Affairs and Minister for Parliamentary Affairs
• C. M. Stephen - politician and Union minister

• Baselios Thoma Didymos I - Catholicos of the East and Malankara Metropolitan
• Kuriakose Elias Chavara - Blessed, co-founder of CMI
• James Kalacherry - Bishop of Changanacherry, who campaigned against the move by C. P. Ramaswami Iyer, the Diwan of Travancore in 1945, to nationalise all schools
• Navajyothi Sree Karunakara, the founder of Santhigiri Ashram
• Mar Thomas Kurialachery - Venerable, first bishop of what would become the Archdiocese of Changanassery, and founder of the Sisters of the Adoration of the Blessed Sacrament^[1]

• Anil Abraham from Mannar who was the father to Rylen Anil