The following highways are numbered 72:

• AH72 Asian Highway 72
• E72 European route E72

• Snowy Mountains Highway

• Alberta Highway 72
• Newfoundland and Labrador Route 72
• Highway 72 (Ontario)

• G72 Expressway

• Matanzas–La Lanza Road (3–72)

• EO72 road

• Road 72

• State road 72

• National Route 72

• Inland Scenic Route

• Interstate 72
• U.S. Route 72
• Alabama State Route 72
• Arizona State Route 72
• Arkansas Highway 72
• California State Route 72
• Colorado State Highway 72
• Connecticut Route 72
• Delaware Route 72
• Florida State Road 72
• Georgia State Route 72
  • Georgia State Route 72 (1930–1941) (former)
• Hawaii Route 72
• Idaho State Highway 72
• Illinois Route 72
• Kentucky Route 72
• Louisiana Highway 72
  • Louisiana State Route 72 (former)
• Maryland Route 72 (former)
• M-72 (Michigan highway)
• Minnesota State Highway 72
  • County Road 72 (Ramsey County, Minnesota)
• Missouri Route 72
• Montana Highway 72
• Nebraska Highway 72 (former)
• Nevada State Route 72 (former)
• New Jersey Route 72
  • County Route 72 (Bergen County, New Jersey)
  • County Route 72 (Ocean County, New Jersey)
• New Mexico State Road 72
• New York State Route 72
  • County Route 72 (Cattaraugus County, New York)
  • County Route 72 (Chautauqua County, New York)
  • County Route 72 (Dutchess County, New York)
  • County Route 72 (Essex County, New York)
  • County Route 72 (Jefferson County, New York)
  • County Route 72 (Livingston County, New York)
  • County Route 72 (Madison County, New York)
  • County Route 72 (Montgomery County, New York)
  • County Route 72 (Orange County, New York)
  • County Route 72 (Putnam County, New York)
  • County Route 72 (Rockland County, New York)
  • County Route 72 (Suffolk County, New York)
• North Carolina Highway 72
• Ohio State Route 72
• Oklahoma State Highway 72
  • Oklahoma State Highway 72 (1930s) (former)
• Pennsylvania Route 72
• South Carolina Highway 72
• Tennessee State Route 72
• Texas State Highway 72
  • Texas State Highway Spur 72
  • Farm to Market Road 72
  • Texas Park Road 72
• Utah State Route 72
• Virginia State Route 72
• West Virginia Route 72
• Wisconsin Highway 72
• Wyoming Highway 72

Territories

• U.S. Virgin Islands Highway 72

• List of highways numbered 72A
• A72 (disambiguation)