The following highways are numbered 48:

• Illawarra Highway

• Alberta Highway 48
• Ontario Highway 48
• Saskatchewan Highway 48

• D48 motorway (Czech Republic) part of European route E462
• I/48; Czech: Silnice I/48

• EO48 road

• Main road 48 (Hungary)

• National Highway 48 (India)

• Road 48

• State road 48

• Japan National Route 48

• National Route 48

• New Zealand State Highway 48

• British A48 (Highnam-Carmarthen)
• British M48 (Olveston-Magor)

• U.S. Route 48
  • U.S. Route 48 (1926) (former)
  • U.S. Route 48 (1965-1991) (former)
• Alabama State Route 48
• Arkansas Highway 48
• California State Route 48
• Delaware Route 48
• Florida State Road 48
  • County Road 48 (Citrus County, Florida)
  • County Road 48 (Sumter County, Florida)
• Georgia State Route 48
• Idaho State Highway 48
• Illinois Route 48
• Indiana State Road 48
• Iowa Highway 48
• Kentucky Route 48
• Louisiana Highway 48
• Maryland Route 48 (former)
• M-48 (Michigan highway)
• Minnesota State Highway 48
  • County Road 48 (Ramsey County, Minnesota)
  • County Road 48 (St. Louis County, Minnesota)
• Mississippi Highway 48
• Missouri Route 48
• Montana Highway 48
• Nebraska Highway 48 (former)
  • Nebraska Recreation Road 48B
• Nevada State Route 48
• New Jersey Route 48
  • County Route 48 (Bergen County, New Jersey)
  • County Route S48 (Bergen County, New Jersey)
  • County Route 48 (Monmouth County, New Jersey)
• New Mexico State Road 48
• New York State Route 48
  • County Route 48 (Allegany County, New York)
  • County Route 48 (Broome County, New York)
  • County Route 48 (Cayuga County, New York)
  • County Route 48 (Chautauqua County, New York)
  • County Route 48 (Chemung County, New York)
  • County Route 48 (Dutchess County, New York)
  • County Route 48 (Essex County, New York)
  • County Route 48 (Franklin County, New York)
  • County Route 48 (Genesee County, New York)
  • County Route 48 (Orange County, New York)
  • County Route 48 (Otsego County, New York)
  • County Route 48 (Putnam County, New York)
  • County Route 48 (Rensselaer County, New York)
  • County Route 48 (Schenectady County, New York)
  • County Route 48 (St. Lawrence County, New York)
  • County Route 48 (Suffolk County, New York)
  • County Route 48 (Sullivan County, New York)
  • County Route 48 (Warren County, New York)
  • County Route 48 (Washington County, New York)
• North Carolina Highway 48
• North Dakota Highway 48
• Ohio State Route 48
• Oklahoma State Highway 48
• Pennsylvania Route 48
• South Carolina Highway 48
• South Dakota Highway 48
• Tennessee State Route 48
• Texas State Highway 48
  • Texas State Highway Loop 48
  • Farm to Market Road 48
  • Texas Park Road 48
• Utah State Route 48
• Virginia State Route 48
  • Virginia State Route 48 (1928-1934) (former)
• West Virginia Route 48 (1920s) (former)
• Wisconsin Highway 48

• List of highways numbered 48A
• A48 (disambiguation)