Route 125 or Highway 125 can refer to multiple roads:

• Winnipeg Route 125
• Nova Scotia Highway 125
• Ontario Highway 125
• Prince Edward Island Route 125
• Quebec Route 125

• National Route 125

• National Highway 125 (Uttarakhand)

• State road 125

• Japan National Route 125

• Mexican Federal Highway 125

• A125 highway (Nigeria)

• A125 road
• B125 road

• Alabama State Route 125
• Arkansas Highway 125
• California State Route 125
• Colorado State Highway 125
• Connecticut Route 125
• Florida State Road 125 (former)
  • County Road 125 (Baker County, Florida)
  • County Road 125 (Bradford County, Florida)
• Georgia State Route 125
• Illinois Route 125
• Iowa Highway 125 (former)
• Kentucky Route 125
• Louisiana Highway 125
• Maine State Route 125
• Maryland Route 125
• Massachusetts Route 125
• M-125 (Michigan highway)
• Missouri Route 125
• New Hampshire Route 125
• New Mexico State Road 125
• New York State Route 125
  • County Route 125 (Cortland County, New York)
  • County Route 125 (Fulton County, New York)
  • County Route 125 (Jefferson County, New York)
  • County Route 125 (Monroe County, New York)
  • County Route 125 (Montgomery County, New York)
  • County Route 125 (Niagara County, New York)
  • County Route 125 (Onondaga County, New York)
  • County Route 125 (Rensselaer County, New York)
  • County Route 125 (Seneca County, New York)
  • County Route 125 (Steuben County, New York)
  • County Route 125 (Tompkins County, New York)
• North Carolina Highway 125
• Ohio State Route 125
• Oklahoma State Highway 125
• Pennsylvania Route 125
• South Carolina Highway 125
• Tennessee State Route 125
• Texas State Highway 125
  • Texas State Highway Loop 125 (former)
  • Texas State Highway Spur 125
  • Farm to Market Road 125
• Utah State Route 125
• Vermont Route 125
• Virginia State Route 125
  • Virginia State Route 125 (1924-1928) (former)
• Washington State Route 125
• West Virginia Route 125 (proposed)
• Wisconsin Highway 125

Territories

• Puerto Rico Highway 125
  • Puerto Rico Highway 125R