Kryptonite is a fictional material from the Superman comic book series.

Kryptonite may also refer to:

• Kryptonite (story arc) a 2007–2008 Superman Confidential story arc
• Kryptonite Man, several DC Comics supervillains

• Kryptonite!, a 2011 Italian film
• Kryptonita (English: Kryptonite), a 2015 Argentinian film
• "Kryptonite" (New Girl), a 2011 television episode

• Apollo (band), originally Kryptonite, a late-1970s American R&B/disco group
• Kryptonite (album), by DJ Fresh, 2010
• "Kryptonite" (3 Doors Down song), 2000
• "Kryptonite" (Don Toliver song), 2024
• "Kryptonite (I'm on It)", a song by Purple Ribbon All-Stars, 2006
• "Kryptonite", a song by James Arthur, 2014
• "Kryptonite", a song by Guy Sebastian from Beautiful Life, 2004
• "Kryptonite", a song by Mario from Go, 2007
• "Kryptonite", a song by James Spaulding from Schizophrenia, 1967

• Kryptonite lock, a brand of bicycle lock
• Operation Kryptonite, a 2007 military operation by British, Dutch and Afghan forces

• Krypton (disambiguation)
• Jadarite, a mineral with a similar formula to the fictional kryptonite
• Pocket Full of Kryptonite, a 1991 album by the Spin Doctors
• CryptoNight