Ketcham is a surname. Notable people with the name include:

• John C. Ketcham (1873–1941), U.S. Representative from Michigan
• John H. Ketcham (1832–1906), U.S. Representative from New York
• William Ketcham (1819–1879), American politician in Wisconsin and lumber executive
• William A. Ketcham (1846–1921), American politician in Indiana and commander of the Grand Army of the Republic
• Winthrop Welles Ketcham (1820–1879), U.S. Representative from Pennsylvania

• Albert H. Ketcham (1870–1935), American orthodontist
• Dennis Ketcham (born 1946), son of Hank Ketcham and inspiration for Dennis the Menace
• Emily Burton Ketcham (1838–1907), American suffragist
• Hank Ketcham (1920–2001), creator of the American cartoon strip Dennis the Menace
• Hank Ketcham (American football) (1891–1986), American gridiron football player
• Henry H. Ketcham (born 1949), Canadian lumber executive, grandson of Hank Ketcham (American football)
• Jennifer Ketcham (born 1983), American former pornographic actress known under the pseudonym "Penny Flame"
• John Ketcham (Indiana surveyor) (1782–1865), American surveyor, building contractor and judge
• John Ketcham (producer-director), American producer
• Ralph Ketcham (1927–2017), American academic
• Robert T. Ketcham, (1889–1978), Baptist pastor and a founder of the General Association of Regular Baptist Churches
• Susan Merrill Ketcham (1841–1930), American painter
• Treddy Ketcham (1919–2006), United States Marine Corps officer
• William H. Ketcham (1868–1921), American Catholic missionary

• All pages with titles containing Ketcham
• Ketchum (disambiguation)
• Roy C. Ketcham High School, a public school in Wappingers Falls, New York, U.S.